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目的 :分析高白细胞性白血病细胞分离术治疗及端粒酶检测的临床价值。方法 :用血细胞分离机 ,对12例高白细胞性急性白血病患者进行白细胞分离治疗 ,并用端粒重复扩增法检测分离细胞和骨髓细胞端粒酶活性。结果 :经白细胞分离术后 ,10 / 12例患者临床症状减轻 ,白细胞计数降低至 5 0× 10 9/ L 以下 ,得以继续顺利化疗 ;患者伴有较高的端粒酶活性 ,其中 6 / 10例临床缓解时仍较高 ,且化疗治疗效果差。结论 :白细胞分离术可有效减轻白血病的细胞负荷 ,避免肿瘤细胞溶解综合征 ;高白细胞性白血病患者伴有较高端粒酶活性的生物特征需进一步研究。
Objective : To analyze the clinical value of separation therapy and telomerase detection of high leukemia leukemia cells. METHODS: Twelve patients with high leukocyte acute leukemia were treated with leukapheresis using a blood cell separator, and telomerase activity was measured in detached cells and bone marrow cells by telomere repeat amplification. RESULTS: After WBC isolation, clinical symptoms of 10/12 patients were alleviated, and the white blood cell count was reduced to below 50 × 10 9 / L, which allowed for continued chemotherapy; patients with high telomerase activity, 6 of 10 Cases of clinical remission are still high, and the effect of chemotherapy is poor. Conclusion : WBC can effectively reduce the cell burden of leukemia and avoid tumor cell lysis syndrome. The biological characteristics of patients with high leukemia with high telomerase activity need further study.