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内毒素(LPS)是临床上引起急性肺损伤和急性呼吸窘迫综合征的重要原因。它直接损伤肺泡细胞是特殊机制;它激活机体导致肺部损伤引起炎性细胞在肺部聚集以及释放各种炎性介质与细胞因子是关键的发病机制;而LPS引起的肺部凝血与纤溶系统失衡均是重要的发病机制。近年来一些新分子的发现,进一步阐明LPS介导急性肺损伤的发病机制。
Endotoxin (LPS) is a clinically important cause of acute lung injury and acute respiratory distress syndrome. It directly injures the alveolar cells is a special mechanism; it activates the body leading to lung damage caused by inflammatory cells in the lungs to gather and release a variety of inflammatory mediators and cytokines are the key pathogenesis; and LPS-induced pulmonary coagulation and fibrinolysis System imbalance is an important pathogenesis. In recent years, the discovery of some new molecules to further clarify the pathogenesis of LPS-mediated acute lung injury.