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目的分析液基细胞学结合阴道镜检查在宫颈上皮内瘤变诊断中的作用。方法对2008年1月至2008年6月来阴道镜门诊就诊的育龄妇女1000名,均进行液基细胞学及阴道镜检查,对其中88例细胞学检查阳性或临床高度怀疑者行阴道镜下活组织病理检查。结果共检出阳性涂片115例,占11.50%,其中未能明确诊断意义的不典型鳞状上皮细胞(ASCUS)69例,占6.90%,低度鳞状上皮内瘤样变(LSIL)20例,占2.00%,高度鳞状上皮内瘤样变(HSIL)17例,占1.70%,不典型腺细胞(AGC)3例,占0.30%,人乳头瘤病毒(HPV)感染者7例,占0.70%。鳞状细胞癌(SCC)5例,占0.50%。与阴道镜下活组织病理检查诊断符合率:SCC为100%(5/5),LSIL为95.24(20/21),HSIL为89.47%(17/19)。结论液基细胞学结合阴道镜检查及镜下定位活检可以提高宫颈上皮内瘤变及早期子宫颈癌的检出率。
Objective To analyze the role of liquid-based cytology and colposcopy in the diagnosis of cervical intraepithelial neoplasia. Methods A total of 1000 women of childbearing age who visited the colposcopy clinic from January 2008 to June 2008 were examined by liquid-based cytology and colposcopy. Colposcopy was performed on 88 cytology-positive or highly-suspected skeletal patients Biopsy. Results A total of 115 positive smears were detected, accounting for 11.50%. Among them, 69 cases were ASCUS, accounting for 6.90%, and low grade squamous intraepithelial neoplasia (LSIL) 20 (2.00%), high grade squamous intraepithelial neoplasia (HSIL) in 17 cases (1.70%), atypical glandular cells (AGC) in 3 cases, accounting for 0.30%, and human papillomavirus (HPV) infection in 7 cases 0.70%. Squamous cell carcinoma (SCC) in 5 cases, accounting for 0.50%. The coincidence rates of biopsy and biopsy under colposcopy were 100% (5/5) for SCC, 95.24 (20/21) for LSIL and 89.47% (17/19) for HSIL. Conclusion Liquid-based cytology combined with colposcopy and microscopic biopsy can improve the detection rate of cervical intraepithelial neoplasia and early cervical cancer.