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目的研究孕妇血型抗体效价与新生儿溶血病(HDN)的关系。方法对夫妇行血型常规和孕妇不规则抗体筛选,检测血型不合的孕妇产前血型抗体效价,并给予药物治疗和跟踪监测。结果 2 235对夫妇中ABO血型不合1 259对,IgG抗A(B)效价≥64者197例;孕妇不规则抗体筛选阳性者3例,经药物干预后,仅9例发生了轻度的HDN。结论产前动态监测血型抗体,对预防和治疗HDN具有重要的临床意义。
Objective To study the relationship between blood group antibody titers and neonatal hemolytic disease (HDN) in pregnant women. Methods The routine blood samples of pregnant women and pregnant women were screened by irregular blood samples, and the titers of prenatal blood group antibody in pregnant women with different blood type were detected. Drug treatment and follow-up monitoring were performed. Results There were 1 259 pairs of ABO blood group in 2 235 couples, 197 in whom IgG anti-A (B) titer ≥64 and 3 in pregnant women with irregular antibody screening positive. Only 9 patients had mild HDN. Conclusions The prenatal dynamic monitoring of blood group antibody has important clinical significance in the prevention and treatment of HDN.