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由东方立克次体所致的恙虫病是引起血管炎性反应的全身性疾病。中枢神经系统(CNS)是其它立克次体感染的重要靶器官。虽然已有恙虫病并发脑炎和脑膜炎的报告,但尚无病原体侵入CNS的直接证据。为了探讨恙虫病患者CNS的受累情况,作者对此进行了前瞻性研究。 材料和方法:研究对象为作者所在医院(位于韩国中西部)1994年10月1日至1995年12月31日收治的25例恙虫病患者。患者入院后第1天和第7天分别进行血清学检查。脑脊液(CSF)标本在入院后及使用强力霉素前留取,检查项目包括细胞计数、糖和蛋白测定,同时采用PCR扩增东方立克次体编码56-KD蛋白基因序列的技术测定立克次体DNA。采用矢状窦血栓性静脉炎患者的CSF
Tsutsugamushi disease caused by Rickettsia orientalis is a systemic disease that causes inflammatory reaction of blood vessels. The central nervous system (CNS) is an important target organ for other rickettsial infections. Although there have been reports of scrub typhus complicated with encephalitis and meningitis, no direct evidence of pathogen intrusion into the CNS is available. In order to investigate the involvement of patients with tsutsugamushi CNS, the authors conducted a prospective study. MATERIALS AND METHODS: Twenty-five patients with scrub typhus were admitted to the author’s hospital (Midwestern part of Korea) from October 1, 1994 to December 31, 1995. Serum tests were performed on the first and seventh day after admission. Cerebrospinal fluid (CSF) samples were collected after admission and before use of doxycycline. The items for examination included cell counting, determination of sugar and protein, and the technique of PCR amplification of the 56-KD protein gene sequence encoded by Rickettsia orientalis Secondarily DNA. CSF in patients with sagittal sinus thrombophlebitis