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目的:研究红景天苷在大鼠小肠的吸收特征。方法:运用大鼠在体单向肠灌流模型,以酚红为标示物,分别研究了不同浓度、肠段红景天苷的吸收情况。结果:红景天苷在pH 5.5~8.0的Krebs-Ringer(K-R)试液中稳定性较好。不同浓度的红景天苷在大鼠各肠段的Peff无显著性差异,表明红景天苷在大鼠小肠内吸收无明显变化,且无自身浓度抑制作用,主要以被动转运方式吸收。十二指肠、空肠、回肠、结肠的肠灌流的有效渗透系数(Peff)、吸收速率参数(Ka)值表明,红景天苷在十二指肠、空肠、回肠的吸收优于结肠。结论:红景天苷在大鼠小肠吸收方式以被动转运为主,且在肠道中易吸收。
Objective: To study the absorption characteristics of salidroside in the small intestine of rats. Methods: The rat model of single intestinal perfused with phenol red as the marker, respectively, the absorption of salidroside at different concentrations and intestine were studied. Results: Salidroside was more stable in Krebs-Ringer (K-R) solution at pH 5.5-8.0. Different concentrations of salidroside in the rat intestines of Peff no significant difference, indicating that salidroside absorption in the rat small intestine no significant change, and no self-concentration inhibition, mainly by passive transport mode of absorption. The effective permeability coefficient (Peff) of intestinal perfusion in duodenum, jejunum, ileum and colon shows that the absorption of salidroside in the duodenum, jejunum and ileum is superior to colon. Conclusion: The salidroside absorption in the small intestine of rats is mainly passive, and is easily absorbed in the intestine.