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目的:了解我院抗菌药致药品不良反应(ADR)发生情况,为临床安全用药提供参考。方法:对我院2007～2009年上报的抗菌药401例ADR进行回顾性分析。结果:401例ADR报告中共涉及33种抗菌药,其中喹诺酮类药引起的ADR最多(25.94%),其次为头孢菌素类(24.69%);以静脉滴注给药途径引起的ADR最常见(78.05%);ADR临床表现以皮肤及其附件损害最多见(49.27%)。结论:应加强抗菌药ADR监测工作,保障患者用药安全。
Objective: To understand the incidence of adverse drug reaction (ADR) caused by antibacterial drugs in our hospital and provide references for clinical safety medication. Methods: A retrospective analysis of 401 cases of ADR reported in our hospital from 2007 to 2009 was conducted. Results: A total of 401 antimicrobial agents were involved in 401 ADRs, of which quinolones caused the most ADR (25.94%), followed by cephalosporins (24.69%). ADR caused by intravenous infusion was the most common 78.05%). The clinical manifestations of ADR were the most damage to the skin and its appendages (49.27%). Conclusion: The ADR monitoring of antibacterials should be strengthened to ensure the safety of patients.