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胰岛素抵抗/高胰岛素血症与肾素-血管紧张素系统在高血压的发生、发展中起着举足轻重的作用。血管紧张素Ⅱ的大部分生理作用都是通过血管紧张素Ⅱ1型受体介导的。过氧化物酶体增殖物激活受体-γ不仅调节糖、脂代谢,还调控着血管紧张素Ⅱ1型受体mRNA的表达,参与高血压和左室重构的发生、发展。
Insulin resistance / hyperinsulinemia and renin-angiotensin system play an important role in the development and progression of hypertension. Most of the physiological effects of angiotensin II are mediated through angiotensin II type 1 receptors. Peroxisome proliferator-activated receptor-γ not only regulates the metabolism of glucose and lipid, but also regulates the expression of angiotensin Ⅱ type 1 receptor mRNA and participates in the occurrence and development of hypertension and left ventricular remodeling.