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为探讨转移相关基因CD_(44V6)与喉鳞癌颈淋巴结转移和其他生物学行为的关系,采用免疫组化SP法对39例喉鳞状细胞癌进行标记分析,结果发现:CD_(44V6)阳性率,淋巴结转移组(88.24％)明显高于无淋巴结转移组(59.09％)(P<0.05),在喉鳞癌Ⅲ级(84％)高于鳞癌Ⅰ～Ⅱ级(50％)(P<0.05)。对CD_(44V6)阳性的组织切片研究发现,在某些切片中不是全部癌细胞均为CD_(44V6)阳性,有部分癌细胞为阴性反应。上述结果表明,在喉鳞癌组织内,存在不同潜能转移的癌细胞亚群,获得CD_(44V6)因子的癌细胞,具有转移的潜能,CD_(44V6)与喉鳞癌的低分化性,高浸润性及转移密切相关。
To investigate the relationship between metastasis-associated gene CD44V6 and cervical lymph node metastasis and other biological behaviors of laryngeal squamous cell carcinoma, 39 cases of laryngeal squamous cell carcinoma were analyzed by immunohistochemistry. The results showed that CD44V6 positive (88.24%) were significantly higher than those without lymph node metastasis (59.09%) (P <0.05), and were significantly higher in grade Ⅲ (84%) than in grade Ⅰ ~ Ⅱ <0.05). CD44V6 positive tissue sections of the study found that in some sections, not all of the cancer cells were CD_ (44V6) positive, some cancer cells were negative. The above results indicated that in 44 cases of laryngeal squamous cell carcinoma, there is a subpopulation of cancer cells with different potential metastasis and CD44V6 cells have the potential of metastasis. CD44V6 is associated with low differentiation and high differentiation of laryngeal squamous cell carcinoma Invasion and metastasis are closely related.