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目的检测早发冠心病(PCHD)患者血浆结合珠蛋白(Hp)水平,观察不同类型早发冠心病患者血浆珠蛋白水平。方法纳入2010年5月～2011年1月PCHD患者72例,同期纳入健康体检者74例作为对照组。将PCHD组依诊断进一步分为稳定性心绞痛组(SA,n=15)、不稳定性心绞痛组(UA,n=36)和急性心肌梗死组(AMI,n=21);检测并比较各组Hp浓度的差异。结果 PCHD组Hp浓度高于对照组,差异有统计学意义[(1.785±0.525)ng/mLvs.(0.869±0.172)ng/mL,P<0.05];SA组、UA组和AMI组Hp浓度分别为(1.699±0.723)ng/mL、(1.685±0.453)ng/mL和(1.946±0.584)ng/mL,组间比较无明显差异(P=0.281)。结论 PCHD患者血浆Hp浓度明显升高,且与类型无关。
Objective To detect the plasma levels of Hp in patients with premature coronary heart disease (PCHD) and to observe the plasma levels of globin in patients with different types of premature coronary heart disease. Methods A total of 72 PCHD patients from May 2010 to January 2011 were enrolled in this study. Totally 74 healthy subjects were included as control group. The PCHD group was further divided into stable angina group (SA, n = 15), unstable angina group (UA, n = 36) and acute myocardial infarction group (AMI, n = 21) Hp concentration differences. Results The Hp concentration in PCHD group was significantly higher than that in control group [(1.785 ± 0.525) ng / mL vs (0.869 ± 0.172) ng / mL, P <0.05] (1.699 ± 0.723) ng / mL, (1.685 ± 0.453) ng / mL and (1.946 ± 0.584) ng / mL, respectively. There was no significant difference between the two groups (P = 0.281). Conclusion The plasma Hp concentration in patients with PCHD was significantly increased, and had no relationship with the type.