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造成难治性肺部感染的原因应从宿主的机体、病原微生物和抗菌药物三者来分析,其中最主要的是机体本身的因素。原因包括全身因素造成的机体免疫功能低下、呼吸道局部的防御功能降低以及致病菌对不断开发的新型抗菌药物的耐药。滥用及不合理使用抗菌药物也是造成难治的原因之一,并导致病原菌产生耐药性、菌群交替、机遇性感染、L型细菌出现和多种病原微生物混合感染。
Causes of refractory pulmonary infection should be from the host’s body, pathogenic microorganisms and antibiotics to analyze the three, the most important of which is the body’s own factors. Reasons include systemic immune system dysfunction, decreased defensive function of the respiratory tract, and resistance of pathogens to the development of new antimicrobials. Abuse and unreasonable use of antimicrobial agents are also one of the causes of refractory disease and lead to the emergence of drug-resistant pathogens, alternation of flora, opportunistic infections, the appearance of L-forms of bacteria and mixed infections with multiple pathogenic microorganisms.