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本文43例HCV RNA阳性的患者随机分别接受α干扰素(IFN-α)或β干扰素(IFN-β)6MU治疗。选出其中16例患者来评价IFN对HCV RNA的影响。这16例抗-HCV均阳性。在治疗前、治疗期间(第1、2和4周)和治疗后(每2个月1次,共6个月)采集血清标本。另选择16例抗-HCV和HCV RNA均阳性的慢性丙型肝炎(CHC)患者作为对照。用逆转录法和套式PCR法检测血清HCV RNA。结果表明,开始16例患者血清HCVRNA均阳性,经IFN治疗后第1周,有11例HCV RNA转阴,2例2周后转阴。在治疗期间,13例HCV RNA转阴的患者,其血清ALT水平恢复正常或接近正常。5
In this paper, 43 patients with positive HCV RNA were randomized to receive interferon-alpha (IFN-α) or interferon-β (IFN-β) 6MU, respectively. Sixteen patients were selected to assess the effect of IFN on HCV RNA. All 16 cases of anti-HCV were positive. Serum samples were collected before treatment, during treatment (weeks 1, 2 and 4) and after treatment (once every 2 months for a total of 6 months). In addition, 16 patients with chronic hepatitis C (CHC) positive for both HCV and HCV RNA were selected as controls. Serum HCV RNA was detected by reverse transcription and nested PCR. The results showed that in the first 16 patients, the serum HCV RNA was positive. In the first week after IFN treatment, 11 cases of HCV RNA turned negative and 2 cases turned negative after 2 weeks. During treatment, serum ALT levels returned to normal or near normal in 13 HCV RNA negative patients. 5