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肝脏纤维化的临床重要性业已通过组织病理学的研究而得以确认。目前人们已经认识到存在着几种形式的肝脏纤维化(由于纤维分隔所引起的静脉扭曲;肝窦的毛细血管化和中央静脉硬化)。除了在肝小叶内的位置以外,肝纤维化伴发的肝功能不全程度也有差异。门脉周围纤维化不伴有炎症或肝细胞界板的破坏,可以不产生临床症状。而肝窦或中央静脉周围的纤维化则有肝病的明显临床表现。这些差异至少在部分程度上与后两种形式的纤维化引起较大的肝窦血流障碍有关。但是,肝细胞功能的改变也反映了正常细胞外基质(extracellularmatrix,ECM)结构及其对实质细胞的生物学
The clinical importance of liver fibrosis has been confirmed by histopathological studies. It has now been recognized that several forms of hepatic fibrosis exist (due to venous distortions caused by fibrous septum; cirrhosis and central venous sclerosis). In addition to the position within the hepatic lobule, there is also a difference in the degree of hepatic insufficiency associated with fibrosis. Peripheral fibrosis is not accompanied by inflammation or destruction of the liver cell demarcation, can produce no clinical symptoms. The sinusoidal or central venous fibrosis is a clear clinical manifestation of liver disease. These differences, at least to some extent, are associated with greater hepatic sinusoidal blood flow disturbances in the latter two forms of fibrosis. However, changes in hepatocyte function also reflect the structure of the extracellular matrix (ECM) and its effect on the biology of parenchymal cells