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目的分析脑梗死后认知功能障碍与高半胱氨酸(tHcy)、类胰岛素样生长因子-1(IGF-1)的相关性。方法选取98例脑梗死患者及45例健康体检者作为研究项目的观察对象,对比脑梗死组与健康体检组血清tHcy、IGF-1浓度;根据蒙特利尔认知评估量表(MoCA)评分结果对脑梗死进行分组,其中认知功能障碍组42例、认知功能正常组56例;对比两组患者血清tHcy、IGF-1浓度,以tHcy、IGF-1作为脑梗死后认知功能障碍的潜在危险因素,进行Logistic多因素回归分析。结果脑梗死组的血清tHcy浓度显著高于健康体检组,血清IGF-1浓度显著低于健康体检组;差异具有统计学意义(P<0.05);认知功能障碍组的血清tHcy浓度显著高于认知功能正常组,血清IGF-1浓度显著低于认知功能正常组;两组数据差异具有统计学意义(P<0.05);Logistic多因素回归分析:高血清tHcy浓度、低血清IGF-1浓度作为脑梗死后认知功能障碍的独立危险因素。结论脑梗死患者存在高水平的血清tHcy及低水平的血清IGF-1,脑梗死后认知功能障碍的发生与tHcy、IGF-1密切相关,高血清tHcy浓度、低血清IGF-1浓度可显著增大脑梗死后并发认知功能障碍的风险。
Objective To analyze the correlation between cognitive dysfunction and homocysteine (tHcy) and insulin-like growth factor-1 (IGF-1) after cerebral infarction. Methods A total of 98 patients with cerebral infarction and 45 healthy subjects were enrolled in this study. Serum concentrations of tHcy and IGF-1 were compared between cerebral infarction group and healthy group. According to the Montreal Cognitive Assessment Scale (MoCA) Infarction were divided into groups, of which 42 cases of cognitive dysfunction group and 56 cases of normal cognitive function group; compared two groups of patients serum tHcy, IGF-1 concentration, tHcy, IGF-1 as a potential risk of cognitive impairment after cerebral infarction Factors, Logistic multivariate regression analysis. Results Serum tHcy concentration in cerebral infarction group was significantly higher than that in healthy control group, serum IGF-1 concentration was significantly lower than that in healthy group (P <0.05), serum tHcy concentration in cognitive impairment group was significantly higher than that in healthy group (P <0.05). Logistic regression analysis showed that tHcy levels in serum, serum IGF-1 level in serum were lower than those in normal cognitive function group Concentration as an independent risk factor for cognitive dysfunction after cerebral infarction. Conclusions There is a high level of serum tHcy and a low level of serum IGF-1 in patients with cerebral infarction. The incidence of cognitive dysfunction after cerebral infarction is closely related to tHcy and IGF-1. High serum tHcy concentration and low serum IGF-1 concentration may be significant Increase the risk of cognitive dysfunction after cerebral infarction.