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阿片类药物的耐受和躯体依赖不仅与阿片受体本身的代偿性适应有关 ,而且还涉及到许多非阿片受体和递质系统。一方面当改变这些非阿片受体的功能后会影响阿片类药物的药理作用 ,例如抑制 5＿ＨＴ重吸收可以增加吗啡镇痛[1 ] ;另一方面阿片类药物慢性处理会引起这些受体系统发生
The tolerance and body dependence of opioids are not only related to the compensatory adaptation of opioid receptors themselves, but also to many non-opioid receptors and neurotransmitter systems. On the one hand, changes in the function of these non-opioid receptors affect the pharmacological effects of opioids. For example, inhibition of 5-HT reabsorption can increase morphine analgesia [1]. On the other hand, chronic opioid treatment causes these receptors to occur systematically