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目的 探讨一氧化氮 (NO)在舌鳞癌发生中的作用。方法 原位杂交法检测体内合成NO的关键酶诱导型一氧化氮合酶 (induciblenitricoxidesynthase ,iNOS)mRNA在 1 0例舌正常组织、1 4例舌白斑、68例舌鳞癌中的表达。结果 iNOSmRNA在舌正常组织 ,舌白斑、舌鳞癌中的表达阳性率分别为 2 0 0 %、57 1 %、72 1 % ,各组别间差异均有显著性 (P <0 0 5)。结论 由iNOS诱导产生的NO可能在舌癌的发生中起着重要的作用
Objective To investigate the role of nitric oxide (NO) in the pathogenesis of tongue squamous cell carcinoma. Methods In situ hybridization was used to detect the expression of inducible nitric oxide synthase (iNOS) mRNA in 10 normal tongue tissues, 14 tongue spots and 68 tongue squamous carcinomas. Results The positive rates of iNOS mRNA in tongue normal tissues, tongue leukoplakia and tongue squamous cell carcinoma were 200%, 571% and 721%, respectively. There were significant differences among the groups (P <0.05). Conclusion NO induced by iNOS may play an important role in the carcinogenesis of tongue cancer