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目的研究感冒热毒清合剂解热作用。方法以耳静脉注射细菌内毒素引起家兔体温升高为指标,考察感冒热毒清对细菌内毒素引起家兔体温升高的影响;按照中药新药治疗感冒的临床研究指导原则进行临床病例观察及疗效判定。结果灌胃感冒热毒清10、5 g生药·kg~(-1)。,在给药后2.5~4.5 h,均能明显抑制细菌内毒素致家兔体温升高,与模型对照组比较,差异有显著性意义;经临床病例观察,退热作用明显,感冒症状消失快。结论感冒热毒清能抑制细菌内毒素引起的家兔体温升高,具有良好的解热作用。
Aim To study the antipyretic effect of flu Rehovsin. Methods The rabbits were induced by bacterial endotoxin in the ear vein to raise their body temperature as an index to investigate the effects of the flu remedy on the increase of body temperature caused by bacterial endotoxin in rabbits. Clinical observation was made according to the clinical research guidelines of new drugs for treating colds Curative effect. The results of intragastric administration of cold toxic drug Qing 10,5 g crude drug · kg ~ (-1). , 2.5 ~ 4.5 h after administration, can significantly inhibit bacterial endotoxin induced rabbits increased body temperature, compared with the model control group, the difference was significant; clinical cases observed, the role of antipyretic, cold symptoms disappear quickly . Conclusion Cold detoxification can inhibit bacterial endotoxin-induced rabbits increased body temperature, with good antipyretic effect.