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目的:探讨抽动障碍(TD)发病与细胞炎症因子的相关性。方法:选取40例外风袭肺肝风内动型TD患儿(TD组)及24名健康儿童(对照组)。采用化学发光法检测两组血浆细胞炎症因子TNF-α、IL-2、IL-6和IL-1β水平。结果:TD组患儿血浆TNF-α、IL-2水平高于对照组(P<0.05);TD组患儿IL-6水平升高的例数多于对照组(P<0.05),但两组IL-1β水平升高的例数无统计学差异(P>0.05)。结论:TD发病与细胞炎症因子水平升高密切相关。
Objective: To investigate the relationship between the incidence of tic disorder (TD) and inflammatory cytokines. Methods: Forty outpatients (TD group) and 24 healthy children (control group) were enrolled in this study. The levels of plasma inflammatory cytokines TNF-α, IL-2, IL-6 and IL-1β in plasma were detected by chemiluminescence method. Results: The levels of plasma TNF-α and IL-2 in TD group were higher than those in control group (P <0.05). The number of IL-6 in TD group was higher than that in control group (P <0.05) No significant difference was found in the number of IL-1β (P> 0.05). Conclusion: The incidence of TD is closely related to the elevation of inflammatory cytokines.