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4％～15％的髋部骨折发生在中风的晚期,而且至少79％在偏瘫侧。作者先前的研究发现这主要是由于失用、VitD缺乏、制动诱导的高钙血症和代偿性甲旁亢等因素导致偏瘫侧骨密度(BMD)降低所致。而作者曾使用过1α-(OH)D_3(VitD_3的活性形式,1,25-(OH)_2D3的前体)治疗中风偏瘫,发现VitD_3能防止偏瘫侧骨密度的进一步减少。Ipriflavone能防止骨钙丢失,有效防治制动诱导的骨量丢失。通过两药12个月的对比试验来评估Ipriflavone的效果。
4% to 15% of hip fractures occur late in stroke, and at least 79% are on the hemiplegic side. Previous studies by the authors found that this was mainly due to a decrease in hemiparetic side-bone density (BMD) due to factors such as dearth, VitD deficiency, brake-induced hypercalcaemia and compensatory hyperparathyroidism. The authors have used 1α- (OH) D_3 (the active form of VitD_3, a precursor of 1,25- (OH) _2D3) in the treatment of stroke and hemiplegia and found that VitD_3 prevented a further decrease in BMD at the hemiparetic side. Ipriflavone prevents calcium loss and effectively prevents brake-induced bone loss. The effect of Ipriflavone was evaluated by a 12-month comparative study of two drugs.