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Angew.Chem.Int.Ed.2014,53,13098~13101通过金属卡宾参与而实现的碳氢键官能团化是构建碳碳键的一种十分可靠和高效的方法.过去的几十年中,基于金属卡宾参与而实现的sp3碳氢键的不对称官能团化已经得到了广泛研究.然而,通过金属卡宾而实现的芳香sp2碳氢键的不对称官能团化仍面临着巨大的挑战.目前除了分子内的反应,或以较为活泼的杂原子芳香环为底物的反应被报道之外,尚无分子间的全碳芳香环sp2碳氢键的不对称官能团化被报道.华东师范大学化学系胡文浩与邢栋
Angew.Chem.Int.Ed.2014,53,13098 ~ 13101 Carbon-hydrogen bond functionalization via the involvement of metal carbenes is a very reliable and efficient method of constructing carbon-carbon bonds. In the past few decades, Asymmetric functionalization of sp3 carbon-hydrogen bonds by metal carbenes has been extensively studied.However, the asymmetric functionalization of aromatic sp2-carbon-hydrogen bonds by metal carbenes still poses a huge challenge.At present, , Or the reaction of the more active heteroatom aromatic ring as a substrate has been reported, there is no asymmetric functionalization of the intermolecular aromatic ring sp2 carbon-hydrogen bonds reported. East China Normal University Department of Chemistry Hu Wenhao And Xing Dong