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目的 :观察自体造血干细胞混合HLA半相合异基因骨髓移植治疗恶性血液病的疗效及移植相关并发症 .方法 :分析 1 995 0 1 / 2 0 0 3 0 1我院 33例自体造血干细胞混合HLA半相合骨髓移植患者的临床资料 .结果 :1 7(5 1 % )例患者发生了轻、中度口腔黏膜炎 ,重症出血性膀胱炎和肝VOD者各 1例 ,白质脑病 1例 ,全身放射治疗后发生脑水肿 1例 ,1例移植期间出现结核性胸膜炎 ,并发间质性肺炎 .对可评估的性别不同的 1 0例供受者性染色体分析发现 3例 (30 % )移植后形成混合嵌合体 ,仅 2例发生皮肤cGVHD .随防 4 2 (6 96 )mo ,1 9例 (5 7.6 % )无病存活 ,4例 (1 2 .1 % )移植相关并发症死亡 ,8例 (2 4 .2 % )术后复发 ,2例 (6 .1 % )发生了移植后MDS .结论 :自体造血干细胞混合HLA半相合异体骨髓移植 ,能够有效诱导GVL效应 ,提高疗效 ,减少复发 ,且并无增加移植相关并发症 .
OBJECTIVE: To observe the curative effect and transplantation-related complications of autologous hematopoietic stem cell-mixed HLA haploidentical allogeneic bone marrow transplantation in the treatment of hematologic malignancies.Methods: The data of 339 patients with autologous hematopoietic stem cell mixed HLA haplotype The clinical data of patients who underwent bone marrow transplantation were compared.Results: Twenty-seven (51%) patients had mild to moderate oral mucositis, 1 case of severe hemorrhagic cystitis and liver VOD, 1 case of white matter encephalopathy, 1 patient developed cerebral edema and 1 patient had tuberculous pleurisy and interstitial pneumonia during transplantation.Analyseable sex difference of 10 donor-recipient sex chromosomes revealed that 3 patients (30%) had mixed embedding In 2 cases, skin cGVHD occurred in only 2 cases, 19 cases (7.66%) survived without TB (96.6%), 4 cases (12.1%) died of transplantation-related complications, and 8 (2.2%) had postoperative recurrence and 2 cases (6.1%) had MDS after transplantation.Conclusion: Autologous hematopoietic stem cells combined with HLA haploidentical allogenic bone marrow transplantation can effectively induce GVL effect, improve curative effect and reduce relapse, No increase in complications related to transplantation.