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以零担物流中遇到最普通也最急需优化的成本来源—配送路径优化和接货整数规划为研究对象，结合江苏百成大达物流有限公司的日常货物运输安排进行分析，利用C-W优化算法和整数规划算法对每天派送中不同的客户地址和条件进行最低成本方案优化，并通过事例推理的方法对这些最低成本方案进行优化组合，建立起了派送与接货一体化考虑的优化系统，并用实例进行了验证。优化结果具有很高的经济价值，能为公司节约不必要的开支，而且节约下的车辆和司机可以配备到其他地区的配送路线中，或者应对一些突发状况，从而提高了公司的资源利用率。“,”In this paper, with the distribution route and cargo pick-up integer programming as the object, we analyzed the routine cargo transportation schedule of the Jiangsu Baicheng Dada Logistics Company, used the C-W algorithm and integer programming algorithm to optimize the customer address and condition in its everyday delivery so as to achieve minimum cost, then through the case-based reasoning, combined and optimized the solutions with the minimum cost, established the optimized system that integrated cargo delivery and pick-up, and at the end, verified its validity through an empirical case.