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目的探讨前列腺素E1(PGE1)在糖尿病足治疗中的疗效。方法 95例患者随机分成对照组45例和PGE1组50例。对照组采取规范的全身治疗和局部治疗;PGE1组在对照组治疗的基础上加用PGE1静脉滴注。结果 PGE1组治愈33例,好转11例,治疗总有效率88.0%,治愈率66.0%;对照组治愈11例,好转9例,总有效率44.4%,治愈率24.4%。PGE1组治愈率、总有效率明显优于对照组(P均<0.05)。PGE1组治愈时间和好转时间分别为(26.1±5.0)和(12.6±4.3)d,明显短于对照组的(41.4±11.1)和(23.4±8.5)d(P均<0.05)。PGE1组静脉注射部位血管发红2例,颜面潮红1例,头晕1例,注射后局部疼痛3例。均在停止给药2h内自行消失。结论 PGE1在糖尿病足治疗中效果确切,可提高治愈率,降低致残率。
Objective To investigate the efficacy of prostaglandin E1 (PGE1) in the treatment of diabetic foot. Methods Ninety-five patients were randomly divided into control group (n = 45) and PGE1 group (n = 50). The control group to take the standard systemic treatment and local treatment; PGE1 group in the control group based on the treatment with PGE1 intravenous infusion. Results The PGE1 group was cured in 33 cases and improved in 11 cases. The total effective rate was 88.0% and the cure rate was 66.0%. In the control group, 11 cases were cured and 9 cases improved. The total effective rate was 44.4% and the cure rate was 24.4%. PGE1 group cure rate, the total effective rate was significantly better than the control group (P all <0.05). The cure time and improvement time in PGE1 group were (26.1 ± 5.0) and (12.6 ± 4.3) days, respectively, which were significantly shorter than those in control group (41.4 ± 11.1) and (23.4 ± 8.5) days (P <0.05). In PGE1 group, there were 2 cases of vascular redness, 1 case of facial flushing, 1 case of dizziness and 3 cases of local pain after injection. All disappeared within 2 hours after stopping administration. Conclusion PGE1 is effective in diabetic foot treatment, which can improve the cure rate and reduce the morbidity.