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最近研究表明,应激下的父母可以将应激遗传给子女,影响后者对疾病的危险,但通过什么样的机制,迄今未清楚。2011年7月21日《Cell》发表的报告反映蝇在应激时,一个转录因子放开它的异染色体,使它们得以散开及复制。麻省医学院遗传学家Olvier Rando(未参与该项研究)称,真正值得关注的是对异染色质的效应可以传给儿女。研究结果还见于酵母,提示许多种系都保留了此表观遗传分子径路,包括人类。90年代起David Barker观察到出生低体重婴儿,以后更易发生心脏病和糖尿病,研究者们提示父母饥饿等的应激体验可
Recent research shows that under stress, parents can transfer their stress to their children and affect the latter’s risk to the disease. However, by what mechanism, so far it is not clear. July 21, 2011 “Cell” reports that when a fly is stressed, a transcription factor releases its heterochromosomes, allowing them to spread and replicate. Olvier Rando, a geneticist at the Massachusetts Medical School who did not participate in the study, said that what really deserves attention is that the effects of heterochromatin can be passed on to children. The findings are also found in yeast, suggesting that many germline families retain this epigenetic pathways, including humans. Since the 1990s David Barker observed that babies born with low birth weight were more likely to develop heart disease and diabetes, and the researchers suggested that stressful experiences such as familial hunger may be