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环孢霉素)cyclosporin)系一种新型强力免疫抑制剂。临床常用于治疗各种免疫疾病和抑制同种异体移值的排斥反应。利福平(Rifampicin)是肝脏药物代谢酶的强效诱导剂,当与环孢霉素联用时可使其清除率升高,从而显著降低环孢霉素血清浓度。近年国外报道,一例男性患者43岁,于接受心脏移植术前一天,投给环孢霉素10mg/kg/日。患者由于结核感染(皮内试验呈阳性反应)同时投给异烟肼(Isoniazid)
Cyclosporin) is a new type of potent immunosuppressant. Clinical commonly used in the treatment of various immune diseases and inhibition of allograft rejection. Rifampicin, a potent inducer of hepatic drug-metabolizing enzymes, increases its clearance when used in combination with cyclosporine, thereby significantly reducing cyclosporine serum concentrations. In recent years, foreign reports, a male patient aged 43, one day prior to receiving heart transplantation, to cyclosporine 10mg / kg / day. Patients were also given Isoniazid due to tuberculosis (positive intradermal test)