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[目的]观察中心静脉导管胸腔闭式引流合康莱特胸腔内灌注对肺癌恶性胸水的治疗作用。[方法]将30例支气管肺癌并中大量胸水的患者随机分为治疗组和对照组,各15例。治疗组予中心静脉导管胸腔闭式引流后再予康莱特胸腔内灌注;对照组于胸腔反复穿刺抽液后康莱特胸腔内灌注治疗。评价比较两组疗效,Karnofsky评分变化及毒副反应。[结果]治疗组完全缓解(PR)3例,部分缓解(CR)10例,无效(NC)2例,有效率为86.67%;对照组CR0例,PR 8例,NC 7例,有效率为53.33%,两组疗效比较有显著性差异。两组Karnofsky标准评分治疗后均有提高,两组Karnofsky标准评分治疗前后变化值比较差异有显著性。[结论]中心静脉导管胸腔闭式引流合康莱特胸腔内灌注治疗对肺癌恶性胸水有较好的疗效,能提高病人的生活质量且无明显毒副反应,值得在临床上推广使用。
[Objective] To observe the therapeutic effects of closed thoracic drainage of central venous catheter and intrathoracic infusion of Kanglaite on malignant pleural effusion of lung cancer. [Methods] Thirty patients with bronchial lung cancer and a large amount of pleural effusion were randomly divided into treatment group and control group, with 15 cases in each group. The treatment group received central venous catheter thoracic closed drainage after perfusion to the Kanglaite; control group in the chest repeatedly puncture fluid after Kanglaite intrapleural infusion treatment. Evaluation of the efficacy of the two groups, Karnofsky score changes and toxic side effects. [Results] In the treatment group, there were 3 cases of complete remission (PR), 10 cases of partial remission (CR), 2 cases of ineffective (NC), and the effective rate was 86.67%. The control group had 0 cases of CR, 8 cases of PR, and 7 cases of NC. 53.33%, there was a significant difference in efficacy between the two groups. The Karnofsky standard scores improved after treatment in both groups. There was a significant difference between the two groups in the changes in the Karnofsky standard score before and after treatment. [Conclusion] The closed thoracic drainage of central venous catheter combined with intrathoracic infusion of Kanglaite has good curative effect on malignant pleural effusion of lung cancer. It can improve the patient’s quality of life and has no obvious toxic and side effects. It is worthy of promotion in clinical practice.