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目的探讨莫沙必利联合多塞平治疗功能性消化不良(FD)的疗效。方法计算机检索PubMed、EMBASE、中国期刊全文数据库、中国维普数据库、中国生物医学文献数据库和万方数据库,检索时间均从建库至2013年7月20日,收集国内外关于莫沙必利治疗FD的随机对照试验(RCT)文献。利用Cochrane协作网提供的RevMan5.2软件对纳入的文献进行Meta分析。结果共纳入9篇随机对照研究文献,合并分析结果显示,莫沙必利与多塞平联合使用与单独使用莫沙必利治疗FD疗效有显著差异[OR 5.63,95%CI(4.01,7.90),P<0.05]。结论莫沙必利联合多塞平治疗FD治疗效果较好。
Objective To investigate the efficacy of mosapride combined with doxepin in the treatment of functional dyspepsia (FD). Methods PubMed, EMBASE, Chinese Journal Full-text Database, China Wipu Database, China Biomedical Literature Database and Wanfang Database were searched by computer. The retrieval time was from database construction to July 20, 2013. The data of Mosapride treatment FD Randomized controlled trials (RCT) literature. Meta-analysis of the included literature was performed using RevMan 5.2 software provided by the Cochrane Collaboration. Results A total of 9 randomized controlled trials were included. The combined analysis showed significant differences in the efficacy of mosapride and doxepin combined with mosapride alone in the treatment of FD [OR 5.63, 95% CI (4.01, 7.90) , P <0.05]. Conclusion Mosapride combined with doxepin in treatment of FD is better.