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低剂量辐射 (lowdoseradiation ,LDR)对机体的兴奋作用指受到LDR后机体出现的免疫力增强、生育能力提高及对肿瘤的抵抗力加强等效应 ,适应性反应指小剂量的预先照射能使机体对其后的大剂量照射产生适应 ,可减轻大剂量照射引起的损伤或后果。目前的研究提示 ,LDR的预先照射可提高其后大剂量放疗的效果 ;小剂量的X射线预先照射 ,有抑制荷瘤小鼠肿瘤生长趋势 ,促进荷瘤小鼠的局部放疗效果的作用 ,而且多次低剂量预照射的效果比一次预照射好。在恶性淋巴瘤患者中进行临床试验的结果也得出了相同的结论 ;对高本底地区居民和医疗受照人群如肺结核患者等的流行病学调查也证实 ,他们总的癌症患病率并没有升高。LDR对肿瘤影响机理尚不清楚 ,有学者认为免疫功能受低剂量照射所激活是LDR抗肿瘤作用的基础 ,而更多的学者倾向于认为LDR可激活DNA的修复系统 ,表现为接受LDR后可使其后接受大剂量照射造成的染色体畸变减少 ,并通过修复酶活性的检测得到证实。
Low-dose radiation (LDR) on the body’s excitement refers to the body after LDR immunity increased, increased fertility and increased resistance to tumors and other effects, adaptive response refers to the small dose of pre-irradiation can make the body right Subsequent high-dose irradiation to adapt to reduce the damage caused by high-dose irradiation or the consequences. The present study suggests that the pre-irradiation of LDR can enhance the effect of subsequent high-dose radiotherapy. Pre-irradiation with low-dose X-rays can inhibit tumor growth in tumor-bearing mice and promote the local radiotherapy effect in tumor-bearing mice, and Multiple low-dose pre-irradiation effect than a good pre-irradiation. The same holds true for the results of clinical trials conducted in patients with malignant lymphoma; epidemiological surveys of high background area residents and those with medical-exposed populations such as tuberculosis also confirmed that their overall prevalence of cancer was Did not rise. LDR on the mechanism of tumor is not clear, some scholars believe that immune function by low dose irradiation is the basis of the anti-tumor effect of LDR, and more scholars tend to think that LDR can activate DNA repair system, the performance of LDR The chromosomal aberrations caused by high doses of irradiation were reduced and confirmed by the detection of the repair enzyme activity.