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IL-12:Interleikin-12(IL-12)was discovered as a cytokine with aunique heterodimeric structure.It was originally found in cultere su-pematant from B lymphobastoid cell lines as natural killer cell stimu-latory factor by M.Kobayashi,et al.in 1989.Recent studies haveshown that the majority of IL-12 is produced by macrophages/mono-cytes following appropriate stimulation.IL-12 Palys a pivotal role inthe regulation of cell-mediated immunity,exerting pleiotropic effectson T cells and natural killer cells.This function is promoted by theIL-12 induced production of interferon-γ from both resting and acti-vated NK and T cells,by the proliferative activity of IL-12 on acti-vated NK and T cells,by enhancing the cytotoxic activity of NKcells,and by supperting cytotoxic T lymphocyte generation.IL-12also promotes the development of naive murine CD4~+ T cells into Thelper type 1(Th1)cells in response to antigen.Based on thesepotent immunomodulatory activities,IL-12 has been shown to havetherapeutic activity in a variety
IL-12: Interleikin-12 (IL-12) was discovered as a cytokine with a unique heterodimeric structure. It was originally found in cultere su-pematant from B lymphobastoid cell lines as natural killer cell stimu-latory factor by M. Kobayashi, et al.in 1989. Recent studies have shown that the majority of IL-12 is produced by macrophages / mono-cytes following appropriate stimulation. IL-12 Palys a pivotal role inthe regulation of cell-mediated immunity, exerting pleiotropic effects on T cells and natural killer cells. This function is promoted by the IL-12 induced production of interferon-γ from both resting and acti-vated NK and T cells, by the proliferative activity of IL-12 on acti-vated NK and T cells, by enhancing the cytotoxic activity of NK cells, and by supperting cytotoxic T lymphocyte generation. IL-12 also promotes the development of naive murine CD4 ~ + T cells into The type 1 (Th1) cells in response to antigen. IL- 12 has been shown to havetherapeutic ac tivity in a variety