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目的:探讨细胞增殖抗原标记物(Ki67)和血管内皮生长因子(VEGF)与喉鳞状细胞癌预后的关系。方法:用免疫组织化学方法研究Ki67和VEGF在32例喉鳞状细胞癌组织中的表达,其中术后3年局部复发5例(复发组),转移3例(转移组),死亡8例(死亡组),生存24例(生存组)。结果:死亡组Ki67和VEGF的表达均明显高于生存组(均P<0.01)。Ki67在复发组和转移组中高表达,均高于未复发组和未转移组(均P<0.01)。VEGF在复发组中亦高表达,高于未复发组(P<0.05)。Cox多因素回归分析发现,Ki67(危险比为3.236,P<0.01)、喉癌的T分期(危险比为1.382,P<0.05)和术前淋巴结转移情况(危险比为0.316,P<0.05)是影响喉鳞状细胞癌预后的独立指标。结论:Ki67和VEGF与喉鳞状细胞癌的预后有关,两指标的高表达预示着喉癌较差的预后,有助于喉癌治疗方案的制定。
Objective: To investigate the relationship between the proliferation of Ki67 and VEGF and the prognosis of laryngeal squamous cell carcinoma. Methods: The expressions of Ki67 and VEGF were detected by immunohistochemistry in 32 cases of laryngeal squamous cell carcinoma. Among them, 5 cases recurred locally (relapse group), 3 cases (metastasis group) and 3 cases died Death group), 24 cases of survival (survival group). Results: The expression of Ki67 and VEGF in the death group were significantly higher than those in the survival group (all P <0.01). Ki67 was highly expressed in both recurrence and metastasis groups, both of which were higher than those of non-recurrence group and non-metastasis group (all P <0.01). VEGF is also highly expressed in the recurrence group, higher than the non-recurrence group (P <0.05). Cox multivariate regression analysis showed that T stage (risk ratio was 1.382, P <0.05) and preoperative lymph node metastasis (risk ratio was 0.316, P <0.05) were significantly higher in Ki67 group Is an independent indicator of the prognosis of laryngeal squamous cell carcinoma. Conclusion: Ki67 and VEGF are associated with the prognosis of laryngeal squamous cell carcinoma. The high expression of both markers predicts the poor prognosis of laryngeal carcinoma and is helpful for the development of laryngeal cancer treatment regimen.