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[目的]分析2005～2007年天津市百日咳流行病学特征及健康人群抗体水平。[方法]利用描述流行病学方法对2005～2007年百日咳疫情资料进行分析,应用ELISA法对2007年健康人群抗体水平进行定量检测。[结果]天津市2005～2007年百日咳平均发病率为0.34/10万,高发人群由2005年的1～3岁年龄组转向2007年的﹤6月龄,流动人口所占比例由2005年的8.62%上升到2007年的14.19%。抗体阳性率为66.42%,7岁以下年龄组低于7岁以上年龄组,差异有统计学意义(P﹤0.001)。[结论]天津市近3年百日咳发病率进一步降低,流行病学特征发生改变,流动儿童发病比例呈逐年上升趋势。健康人群抗体水平低于规范要求的标准。为防止天津市百日咳的再现,应进一步做好适龄儿童的免疫接种,加强流动人口预防接种管理,适时调整百日咳免疫策略。
[Objective] To analyze the epidemiological characteristics of pertussis in Tianjin from 2005 to 2007 and the level of antibody in healthy population. [Methods] Descriptive epidemiological methods were used to analyze the data of pertussis epidemic from 2005 to 2007, and the antibody levels of healthy population in 2007 were quantitatively detected by ELISA. [Results] The average prevalence of whooping cough in Tianjin was 0.34 / lakh in 2005-2007. The high-risk population turned from 1-year-old to 3-year-old in 2005 to <6-month-old in 2007. The proportion of floating population increased from 8.62 in 2005 % Rose to 14.19% in 2007. The positive rate of antibody was 66.42%. The age below 7 years old was lower than the age above 7 years old, the difference was statistically significant (P <0.001). [Conclusion] The incidence of pertussis decreased further in Tianjin in recent 3 years, and the epidemiological characteristics changed. The incidence of migrant children showed an upward trend year by year. Antibody levels in healthy population are below the standards required by the code. In order to prevent the recurrence of whooping cough in Tianjin, we should further make immunization of school-aged children, strengthen the vaccination management of floating population, and timely adjust the immunization strategy of pertussis.