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目的:了解去甲万古霉素在某院ICU中的使用情况,探讨合理应用去甲万古霉素的方法。方法:调查2014-2015年某院80例使用去甲万古霉素病例,根据《抗菌药物临床应用指导原则》就其用药指征,用法用量及细菌病原学检查等方面进行调查分析。结果:80例病例中,患者平均年龄为(67±16)岁,平均住院时间(16.4±10.6)天,应用去甲万古霉素平均天数8.7±4.6,根据药敏结果提示用药例24,有效率73%,但该院ICU应用甲万古霉素仍存在很多问题,如过分经验性用药、无指针用药,适应证过宽、联合用药无指征及用药时间过长或过短,不根据患者肾功能情况用药等。结论:针对该院ICU临床应用去甲万古霉素存在的问题,说明开展特殊使用级抗菌药的限制性措施,严格控制用药指征,减少经验性用药,根据药敏提示用药,提高临床疗效是非常必须的。
Objective: To understand the use of norvancomycin in a hospital ICU, to explore the rational use of norvancomycin. Methods: A total of 80 cases of norvancomycin in a hospital from 2014 to 2015 were enrolled in this study. According to the Guiding Principles of Clinical Application of Antibacterials, the indications, dosage and bacterial etiology of the drug were investigated. Results: In 80 cases, the mean age of patients was (67 ± 16) years, the average length of hospital stay was (16.4 ± 10.6) days, the average number of days of norvancomycin was 8.7 ± 4.6. According to the results of drug susceptibility test, Efficiency of 73%, but the hospital ICU application of vancomycin there are still many problems, such as excessive empirical medication, no pointer medication, indications too wide, no indications for combination therapy and medication time is too long or too short, not according to the patient Kidney function medication. Conclusion: The clinical application of norvancomycin in the hospital for the existence of the problem, indicating the use of special grade antimicrobial agents restrictive measures, strict control of drug indications and reduce the empirical medication, according to drug sensitivity tips to improve clinical efficacy is Very necessary.