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目的：为探讨奥曲肽降低门脉压力及与血浆胰高糖素（ＧＧ）的关系，观察奥曲肽对肾功能的影响。方法：应用彩色多普勒检测１５例肝硬化病人静脉滴注奥曲肽前后门脉系统及侧支循环（胄左静脉）血流动力学的改变、血浆ＧＧ水平的变化以及肾功能的改变。结果：奥曲肽可有效减少门脉及侧支循环血流（Ｐ＜０．０５），静脉滴注奥曲肽后血浆ＧＧ显著下降（Ｐ＜０．０５），肾功能轻度减低（Ｐ＞０．０５），结论：奥曲肽有利于治疗食管静脉出血，其降低门脉压机制可能是由于抑制了胰高糖素的释放，奥曲肽对肝硬化病人的肾功能无明显影响。
OBJECTIVE: To investigate the effect of octreotide on portal pressure and its relationship with plasma glucagon (GG), observe the effect of octreotide on renal function. Methods: The changes of hemodynamics, plasma GG and renal function in 15 patients with cirrhosis before and after intravenous infusion of octreotide were examined by color Doppler. Results: Octreotide could effectively reduce the portal vein and collateral circulation blood flow (P <0.05). After intravenous injection of octreotide, plasma GG decreased significantly (P <0.05) and renal function decreased slightly (P> 0.05 ). Conclusion: Octreotide is good for the treatment of esophageal venous hemorrhage. Its mechanism of lowering portal pressure may be due to inhibition of the release of glucagon. Octreotide has no significant effect on the renal function of patients with cirrhosis.