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蝰蛇(Vipera russelli Siamensis Smith)又名百步金钱蛇,主要分布于广东、广西、福建及台湾的丘陵山区,是我国危害较大的十种毒蛇之一。目前国内的蛇药对治疗蝰蛇咬伤有显效者甚少,实验研究资料也缺。为了寻找抗蝰蛇毒的高效药物,以适应蛇伤治疗的需要,对多种中西药进行了初步的实验筛选,结果表明:α-糜蛋白酶早期局部封闭是治疗蝰蛇咬伤的一种新途径。现将筛选实验结果报告如下: 一、实验材料与方法(一)实验材料1.蛇毒:喹蛇毒干燥结晶,由本教研组及福建医科大学药理教研组供给,置干燥器内保存备用。2.药物(1) α-糜蛋白酶:结晶状白色粉末,每安瓿含量5毫克。上海生物化学制药厂出品。(2) 破布艾:自采于广州市草地。(3) 红雀珊瑚根:海南岛白沙县人民医院提供。
Vipera russelli Siamensis Smith, also known as the hundred-foot money snake, is mainly distributed in the hilly areas of Guangdong, Guangxi, Fujian, and Taiwan. It is one of the ten most poisonous snakes in China. At present, domestic snake medicine has very little effect on the treatment of snake bite, and experimental data are also lacking. In order to find a highly effective anti-snake venom drug to meet the needs of snakebite treatment, a preliminary experimental screening was conducted for a variety of Chinese and Western medicines. The results showed that: early partial closure of α-chymotrypsin is a new way to treat snake bite. . Now the screening test results are reported as follows: First, the experimental materials and methods (a) experimental materials 1. Snake venom: quinoxaquine dry crystallization, by the teaching and research group and Fujian Medical University pharmacological teaching and research group supply, placed in a desiccator stored back. 2. Drug (1) α-chymotrypsin: Crystalline white powder, 5 mg per ampule. Shanghai Biochemical Pharmaceutical Factory produced. (2) Burai Ai: Since it was cultivated in the grasslands of Guangzhou City. (3) Cardinal coral root: provided by People’s Hospital of Baisha County, Hainan Island.