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地中海贫血是以人血红蛋白珠蛋白链之一合成减少或缺乏为特点的一组复杂多样的血红蛋白合成异常的遗传性疾患。蛋白合成中的障碍是异源性的,可由DNA→HnRNA→mRNA→珠蛋白过程中的几种分子异常所造成。[β-地中海贫血的分子学基础] β~+-地中海贫血大部分β-地中海贫血病人的β-珠蛋白合成机能并没有完全丧失,仅呈明显减少,合成量相当于正常人的5～30%。这些病例称为β~+-地中海贫血。
Thalassemia is a hereditary disorder characterized by a complex and diverse combination of hemoglobin synthesis characterized by diminished or lack of synthesis of one of the human hemoglobin globin chains. Obstacles in protein synthesis are heterologous, caused by several molecular abnormalities in the process of DNA → HnRNA → mRNA → globin. [β-thalassemia molecular basis of] β ~ + - Thalassemia β-globin synthesis in most β-thalassemia patients did not completely lost, only a significant reduction in the amount of synthesis equivalent to normal 5 to 30 %. These cases are called β ~ + - thalassemia.