A simple and rapid model of vascular calcification

• 作 者: Mingjun Gu Lianyong Liu Chaobao Zhang Juan Chen Xiangqi Li
• 机 构: Department of Endocrinology,Shanghai Gongli Hospital,The Second Military Medical University,Shanghai
• 出 处: 生物化学与生物物理学报（英文版）
• 发表日期: 2021年5期

Vascular calcification is the aggregation and deposition of hydroxya-patite crystals within arterial wall cells,which can lead to increased vascular wall hardness,decreased compliance,thrombosis,and plaque rupture,and is an important factor for the high incidence and mortality of vascular diseases[1].Arterial calcification was dis-covered 5000 years ago in the Iceman[2].Nowadays,vascular cal-cification has become a very common adverse phenotype of vascular lesions,a common phenotypic feature of diabetes,atherosclerosis,chronic kidney disease,hypertension,and other diseases,as well as an independent risk factor for its occurrence,development,and death[3].Vascular calcification is also an independent risk factor and a sign of disease worsening.For example,in patients with diabetes and chronic kidney disease,accelerated calcification occurs in the vascular intima,media,and heart valves[4].The incidence of vascu-lar calcification increases with age,however even young people have a significant proportion of vascular calcification[5].However,there is no effective clinical response to this,especially no specific drugs to treat it.Therefore,the study of vascular calcification will not only improve our understanding of the pathogenesis of diseases and the aging mechanism but also help to develop new treatment strategies and drugs for these diseases.