论文部分内容阅读
作者对儿童在四价脑膜炎球菌多糖菌苗接种后1个月和1年总的和功能性抗体应答进行测定,并对总荚膜多糖抗体(CPA)和功能性抗体间的关系、预防接种对口咽脑膜炎球菌和乳屑球菌定居的影响及菌苗的不良应率等作了调查.在加拿大安大略东部和魁北克西部,选择225000名6月龄至19.9岁儿童作前瞻性调查,分为7个年龄组,从中随机选择345人作抗体测定.每名儿童在三角肌区或大腿前侧皮下接种菌苗0.5ml.菌苗为脑膜炎球菌多糖抗原冻干制剂,0.5ml含A、C、Y和W-135群各50μg.在接种前、接种后1个月和1年收集人口学资料、作口咽部细菌培养和抗体测定.
The authors measured total and functional antibody responses at 1 month and 1 year after vaccination of tetravalent meningococcal polysaccharide vaccine in children and evaluated the relationship between total capsular polysaccharide antibody (CPA) and functional antibody, vaccination Investigated the effects of oropharyngeal meningococci and C. paucimobilis colonization and the rate of adverse reactions to the vaccine etc. In the eastern part of Ontario, Canada and western Quebec, 225000 children between 6 months and 19.9 years of age were selected for prospective investigation and divided into 7 Age group, randomly selected from 345 for antibody determination.Each child was inoculated subcutaneously in the deltoid area or thigh 0.5 ml vaccine was meningococcal polysaccharide antigen lyophilized preparation, 0.5ml containing A, C, Y and W-135 groups, 50 μg each. Demographic data were collected before inoculation, 1 month and 1 year after inoculation for oropharyngeal bacterial culture and antibody assays.