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过氧化物酶体增殖物激活受体是配体激活的转录因子,属于核激素受体超家族成员。它调控靶基因的转录,参与体内的许多生理病理过程。过氧化物酶体增殖物激活受体可在多种免疫活性细胞、内皮细胞、血管平滑肌细胞和肾系膜细胞等中表达,可通过改善胰岛素抵抗和改善糖、脂代谢紊乱,发挥抗动脉粥样作用;还可通过对巨噬细胞、平滑肌细胞及血管内皮功能的影响,阻止动脉粥样硬化的形成。本文结合近年来过氧化物酶体增殖物激活受体在抗炎作用方面的研究,探讨其在动脉粥样硬化过程中的抗炎症方面的作用机制。
Peroxisome proliferator-activated receptor is a ligand-activated transcription factor and belongs to the nuclear hormone receptor superfamily. It regulates the transcription of target genes and participates in many physiological and pathological processes in the body. Peroxisome proliferator-activated receptor expression in a variety of immune cells, endothelial cells, vascular smooth muscle cells and mesangial cells, etc., by improving insulin resistance and improve glucose and lipid metabolism disorders play anti-porridge Like effect; but also through the macrophages, smooth muscle cells and vascular endothelial function, to prevent the formation of atherosclerosis. In this paper, in recent years, peroxisome proliferator-activated receptor in the anti-inflammatory effects of research to explore its anti-inflammatory mechanism in the process of atherosclerosis.