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氯碘羟喹从1934年开始作为一种口服抗菌药广泛应用于胃肠道感染性疾病,后来因为发现其能诱发亚急性脊髓视神经病而被限制使用。2005年开始,陆续有研究报道,氯碘羟喹具有诱导癌细胞凋亡的作用,随后针对氯碘羟喹抗癌作用机制的一系列研究逐渐开展,并证实其能作为铜、锌等金属离子载体,通过多种细胞通路诱导癌细胞的凋亡,因此氯碘羟喹抗癌作用的研究得到重视。本文就氯碘羟喹抗癌机制的研究进展做一综述。
Since 1934, clioquinol has been widely used as an oral antibacterial for gastrointestinal infectious diseases and was later restricted because of its ability to induce subacute spinal optic neuropathy. Beginning in 2005, one after another reported that clioquinol has the effect of inducing apoptosis of cancer cells. Subsequently, a series of researches on the anticancer mechanism of clioquinol have been carried out gradually and confirmed that it can be used as copper, zinc and other metal ions Vector, through a variety of cellular pathways to induce apoptosis of cancer cells, so the role of clioquinol anti-cancer attention. This article reviews the progress of anticancer mechanism of chloroquine.