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作者研究了先前存在抗—HBs 而后出现急性乙型肝炎病毒感染的一例病者。这例病者体内的抗—HBs 是特异性的抗—d,而不是特异性的抗—a。一般认为,感染HBV 后产生的抗体能保护宿主对抗同型或异型 HBV 的再感染,推测是因为存在特异性的共同决定簇 a。先前存在特异性的抗—d 的抗—HBs,暴露于 HBV 的其他亚型(ayw)后,也就无保护作用,出现HBsAg 阳性的急性肝炎。病者在急性感染 HBV ayw 亚型后出现抗—y 反应性增高,而相应抗—d 反应性降低,而且几乎没有抗—a 反应性,说明病毒对 a 抗原决定簇的非反应性是持续的。
The authors studied a patient who had previously had anti-HBs and then developed an acute hepatitis B virus infection. The anti-HBs in this patient are specific anti-d, but not anti-a. It is generally accepted that antibodies raised after infection with HBV can protect the host from re-infection with isotype or heterotypic HBV, presumably because of the specific co-determinants a. Anti-HBs that had previously been found to have specific anti-d have no protective effect after exposure to ayw of HBV, resulting in HBsAg-positive acute hepatitis. Patients with acute hepatitis ayw infection subtype of anti-y response increased, while the corresponding anti-d reactivity decreased, and almost no anti-a reactivity, indicating that the virus non-responsiveness to a antigenic determinant is sustained .