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当热原输入人体时,其组织被损伤,活性物质(组胺、5—羟色胺、缓激肽、前列腺素等)被激活或释放,引起阻力血管收缩,毛细血管扩张,渗透性增加,使血浆大量进入组织,回心血量减少,心输出量下降,而致微循环障碍,造成血压下降,重者可出现休克。 过去,多采用异丙嗪作为治疗热原反应的首选药物。异丙嗪能拮抗组胺引起的部分毛细血管扩张和通透性增加,并具有镇静作用。但在部分人中易引起兴奋、燥动,大剂量可致惊厥和锥体外系症状,尤其是小儿多见。
When pyrogen is introduced into the human body, the tissue is damaged and the active substances (histamine, serotonin, bradykinin, prostaglandin, etc.) are activated or released, causing resistance vasoconstriction, telangiectasia and permeability, A large number into the organization, back to the heart to reduce blood volume, cardiac output decline, resulting in microcirculation, resulting in decreased blood pressure, severe cases may have shock. In the past, more use of promethazine as the preferred drug for the treatment of pyrogen response. Promethazine can antagonize histamine-induced partial telangiectasia and increased permeability, and has a sedative effect. But in some people easily cause excitement, dryness, high doses can cause convulsions and extrapyramidal symptoms, especially in children more common.