癌症疼痛的临床及药物治疗效果分析

• 作 者: 黄佑庆
• 机 构: 昆明医学院第二附属医院疼痛科,
• 出 处: 中国医疗前沿
• 发表日期: 2010年04期
• 关键词: 癌症 药物治疗 疼痛 疗效 不良反应

目的探讨癌症疼痛的三阶梯药物治疗的效果。方法对我院2007年1月～2009年12月收治的中晚期恶性肿瘤120例给予规范的三阶梯止痛治疗,分析其疗效及不良反应情况。结果治疗两周后轻度疼痛的缓解率为100%,中度疼痛的缓解率为94.3%,中度疼痛的缓解率为90.8%,总缓解率为92.5%;治疗期间常见的不良反应主要为便秘,发生率为11.7%,给予口服大便软化剂或缓泻剂及饮食指导后,便秘症状明显缓解。本组患者中没有1例由于不良反应而终止用药,也没有1例出现精神依赖及呼吸抑制。结论规范的三阶梯药物治疗止痛效果良好,不良反应的发生率低,是安全可行的。

Objective To investigate the effect of three-step drug therapy for cancer pain. Methods A total of 120 patients with advanced stage malignant tumors admitted to our hospital from January 2007 to December 2009 were given standard three-step analgesic therapy and their curative effects and adverse reactions were analyzed. Results Two weeks after treatment, the rate of mild pain relief was 100%, the moderate pain relief rate was 94.3%, the moderate pain relief rate was 90.8% and the total response rate was 92.5%. The common adverse reactions during treatment were Constipation, the incidence was 11.7%, given oral stool softener or laxatives and diet guidance, constipation symptoms significantly alleviated. None of the patients in this group discontinued treatment due to adverse reactions, nor did they experience any psychic dependence or respiratory depression. Conclusion The standard three-step drug therapy has good analgesic effect and low incidence of adverse reactions, which is safe and feasible.