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siRNA是 2 1～ 2 3个nt的短双链RNA ,它的 3′端有 2个AA的突出 ,结构稳定 ,半衰期长 ,能在低于反义核苷酸几个数量级的浓度下使靶基因降至极低水平甚至完全“敲除”。可单独或与其它现有的治疗手段一同用于肿瘤治疗
siRNAs are 21 to 23 nt short double-stranded RNAs with 2 AA overhangs at their 3 ’ends. They are structurally stable and have long half-lives. They target at several orders of magnitude lower than antisense nucleotides Gene down to very low levels or even completely “knocked out.” Tumor therapy can be used alone or in combination with other existing treatments