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为研究多噻烷急性中毒的解毒药物 ,首先建立小鼠多噻烷急性中毒模型 :给小鼠 50 %的多噻烷 2 50mg/kg(LD50 189 3mg/kg) ,经口灌胃染毒 ,使其引起重度中毒 ,选用 16种药物 ,以不同的剂量、时间和途径给药。结果表明 :依地酸二钠钙 (CaNa2 EDTA)、二氯化钴、硝酸钴、氢溴酸东茛菪碱、二巯基丙磺酸钠 (DMPS)、枸橼酸铁铵、氢化可的松加维生素C加 10 %葡萄糖等均有解毒作用。提示小鼠多噻烷急性中毒可用多种药物解毒 ,其中以依地酸二钠钙、二氯化钴、硝酸钴、氢溴酸东茛菪碱等效果最佳。
To study the acute toxicity of polythiazine poisoning drugs, first to establish a mouse polythiazine acute poisoning model: 50% mouse polythiane 2 50mg / kg (LD50 189 3mg / kg), oral gavage, To cause severe poisoning, the choice of 16 kinds of drugs, in different doses, time and route of administration. The results showed that calcium disodium edetate (CaNa2 EDTA), cobalt dichloride, cobalt nitrate, scopolamine hydrobromide, sodium dimercaptopropionate (DMPS), ammonium ferric citrate, hydrocortisone Add vitamin C plus 10% dextrose and detoxification. Prompt mouse polythiazine acute poisoning can be detoxified with a variety of drugs, of which edetate disodium calcium, cobalt dichloride, cobalt nitrate, scopolamine hydrobromide and other best.