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肺动脉平滑肌细胞(ＰＡＳＭＣ)异常增殖是肺动脉高压发病的中心环节,也是其重要的病理改变之一,因此研究其增殖调控机制对于肺动脉高压的防治具有重要意义。ＰＡＳＭＣ异常增殖是细胞促增殖和抑增殖因素失去平衡的结果。以往的研究多集中于促增殖因子如内皮素、血管紧张素等,但
Abnormal proliferation of pulmonary artery smooth muscle cells (PASMC) is one of the important pathological changes of pulmonary hypertension. Therefore, to study the mechanism of its proliferation control is of great significance for the prevention and treatment of pulmonary hypertension. Abnormal proliferation of PASMC is a result of unbalanced proliferation and proliferation inhibition of cells. Previous studies have focused more on the proliferation of factors such as endothelin, angiotensin, etc. However