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为探讨溴氰菊酯对大鼠脑组织代谢型谷氨酸受体 (m Glu R)的影响 ,采用放射性配基受体结合试验研究了溴氰菊酯对大鼠大脑皮层和海马 m Glu R结合功能的影响。结果表明 :溴氰菊酯分别在 2× 10 - 8～ 2× 10 - 4 mol/ L和 2× 10 - 1 2 ～2× 10 - 4 mol/ L剂量范围内能增加大脑皮层和海马突触膜 m Glu R与 3H - Glu的特异结合量 ,并呈现剂量效应关系。与对照组相比 ,溴氰菊酯分别在 2× 10 - 6 ～ 2× 10 - 4 mol/ L和 2× 10 - 1 0 ～ 2× 10 - 4 m ol/ L剂量范围内显著增加大脑皮层和海马突触膜m Glu R与 3H- Glu的特异结合量。这一体外试验结果说明溴氰菊酯能增强大脑皮层和海马突触膜 m Glu R对 Glu的亲和力
In order to investigate the effect of deltamethrin on metabotropic glutamate receptor (mGluR) in rat brain, radioligand receptor binding assay was used to study the effect of deltamethrin on mGluR in rat cerebral cortex and hippocampus Combined with the impact of function. The results showed that deltamethrin could increase the synapses of cerebral cortex and hippocampus in the doses of 2 × 10-8 ~ 2 × 10-4 mol / L and 2 × 10-1 2 ~ 2 × 10-4 mol / L respectively The specific binding of membrane m Glu R to 3H - Glu showed a dose - response relationship. Compared with the control group, deltamethrin increased the cerebral cortex significantly in the range of 2 × 10-6 ~ 2 × 10-4 mol / L and 2 × 10-10 ~ 2 × 10-4 mol / L, respectively And the specific binding of m Glu R to 3H-Glu in the hippocampal synaptic membrane. This in vitro test showed that deltamethrin enhances the affinity of m Glu R to Glu in synaptic membranes of the cerebral cortex and hippocampus