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[目的]探讨卵巢上皮性癌(EOC)组织中血管生成拟态(VM)存在状况及其临床意义。[方法]收集临床病理资料完整的EOC病例94例,运用免疫组织化学(SP法)和组织化学方法进行CD31和PAS双重染色观察EOC组织中是否存在VM。[结果]在11.7%(11/94)的EOC组织中存在VM。在中低分化组中的VM阳性率高于高分化组(χ2=10.239,P<0.05)。Ⅲ～Ⅳ期组VM阳性率高于Ⅰ～Ⅱ期组(χ2=7.541,P<0.05)。[结论]EOC组织中存在VM,且恶性度越高的EOC形成拟态的能力越强,可能促进肿瘤侵袭与转移。
[Objective] To investigate the status of vasculogenic mimicry (VM) in ovarian epithelial carcinoma (EOC) and its clinical significance. [Methods] A total of 94 patients with EOC were collected. The immunohistochemistry (SP method) and histochemical method were used to detect the presence or absence of VM in EOC tissues by CD31 and PAS double staining. [Results] VMs were present in 11.7% (11/94) of EOC tissues. The positive rate of VM in moderately and poorly differentiated group was higher than that in well differentiated group (χ2 = 10.239, P <0.05). The positive rate of VM in stage Ⅲ ~ Ⅳ was higher than that in stage Ⅰ ~ Ⅱ (χ2 = 7.541, P <0.05). [Conclusion] There is VM in EOC tissue, and the more malignant the EOC, the stronger its mimicry ability is, which may promote tumor invasion and metastasis.