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目的了解三门峡市大骨节病病情现状,为大骨节病防治提供依据。方法按照国家及河南省《2007年地方病防治项目技术实施方案》的要求,2008年在三门峡市大骨节病病区选择地形、地貌、生产及生活方式上具有代表性的陕县张村乡窑店、庙洼村,灵宝市朱阳镇朱阳村进行7～12岁儿童大骨节病临床调查,同时拍右手X线片、采集部分儿童发样和当地粮样。儿童发硒、粮食硒测定采用23,一二氨基萘荧光法。在灵宝市、渑池县、陕县、卢氏县大骨节病病区乡进行16岁以上成人大骨节病病情调查。结果共检查7～12岁儿童190人,未检出大骨节病临床病例;拍摄右手X线片190人,X线阳性3人,检出率为1.58%(3/190)。共调查16岁及以上的常住人口16 222人,大骨节病临床检出率为6.65%(1 079/16 222),其中I度为4.46%(723/16 222),Ⅱ度为1.82%(295/16 222),Ⅲ度为0.38%(61/16 222)。儿童发硒平均值为(0.319±0.128)mg/kg,粮食硒平均值为(0.031±0.009)mg/kg。结论三门峡市儿童大骨节病病情已基本控制,成人大骨节病病情较为严重,应继续开展病情监测,加强对成人大骨节病的防治工作,特别是要加强以治疗现患病人为目的的二级预防。
Objective To understand the status of Kashin-Beck disease in Sanmenxia and to provide basis for the prevention and treatment of Kashin-Beck disease. Methods In accordance with the requirements of the “Enforcement Plan for Endemic Diseases Prevention and Treatment Project in 2007” of Henan Province and Henan Province, in 2008, the village of Zhangcun Township, Shanxian County, Shanxian County, where the selection of terrain, physiognomy, production and life style are all selected, , Temple depression village, Zhu Yang Village, Zhu Town, Lingbao City, 7 to 12-year-old children with Kashin-Beck disease clinical investigation, while taking the right hand X-ray film collection of some children samples and local food samples. Selenium children, grain selenium determination using 23, a two amino naphthalene fluorescence method. In Lingbao City, Mianchi County, Shanxian County, Lashi County Kashin-Beck disease in adults over the age of 16 adult Kaschin Beck disease survey. Results A total of 190 children aged 7-12 years were examined, and no Kashin-Beck disease cases were detected. There were 190 right-angled X-ray films and 3 X-ray positive cases with a detection rate of 1.58% (3/190). A total of 16 222 permanent residents aged 16 and above were investigated. The prevalence rate of Kashin-Beck disease was 6.65% (1 079/16 222), of which I degree was 4.46% (723/16 222) and Ⅱ degree was 1.82% ( 295/16 222), and the third degree was 0.38% (61/16 222). The average value of selenium in children was (0.319 ± 0.128) mg / kg, and that of grain selenium was (0.031 ± 0.009) mg / kg. Conclusion The prevalence of Kaschin Beck disease in Sanmenxia City has been basically controlled. Adult Kashin-Beck disease is more serious. Disease surveillance should be continued and the prevention and treatment of adult Kaschin-Beck disease should be intensified. In particular, to strengthen the treatment of patients with existing disease, prevention.