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环磷酰胺(Cyclophosphamide,CPA)是具有抗肿瘤及免疫抑制双重药理作用的药物。研究已发现其对肿瘤细胞的杀伤作用是通过诱导细胞调亡而实现的[1],胸腺作为中枢性免疫器官,在免疫疫系统中起重要作用,本研究探讨CPA能否在体内诱导大鼠胸腺细胞调亡及其作用途径。1 材料和方法1.1
Cyclophosphamide (CPA) is a dual anti-tumor and immunosuppressive pharmacological agents. Studies have found that its killing effect on tumor cells is achieved through the induction of apoptosis [1], the thymus as a central immune organ plays an important role in the immune system. This study was to investigate whether CPA can induce in vivo rat Thymocyte apoptosis and its mechanism of action. 1 Materials and methods 1.1