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目的：我们已成功地建立了以邻苯二酚氧化酶ｘｙ１Ｅ为靶基因，ｐＥＳｎｘ穿梭质粒为载体的ｘｙ１Ｅ－ＩＣＲ转基因小鼠致突变检测模型，为使该模型最终能成为商品并推广应用，必须繁育并筛选出ｘｙ１Ｅ－ＩＣＲ转基因小鼠的纯合子，从而建立纯系转基因小鼠。为此本研究对ｘｙ
OBJECTIVE: We have successfully established a mutagenicity detection model for xy1E-ICR transgenic mice with catechol oxidase xy1E as a target gene and pESnx shuttle plasmid as a vector. In order to eventually make this model a commercial product and promote its use, The homozygous xy1E-ICR transgenic mice were bred and screened to create pure-line transgenic mice. For this reason the study of xy